LOKELMA is a prescription medication for the treatment of high levels of potassium in the blood (hyperkalemia) in adults. LOKELMA should not be used as an emergency treatment for life-threatening hyperkalemia because of its delayed onset of action.
IMPORTANT SAFETY INFORMATION FOR LOKELMA® (sodium zirconium cyclosilicate)
What is the most important thing I should know about LOKELMA?
Don’t take LOKELMA if you have:
- severe constipation, a blockage (obstruction) in your bowel, or hard stool that will not pass (impaction)
- problems with your bowel movements after surgery
LOKELMA may not work and may worsen gastrointestinal conditions.
LOKELMA can cause fluid retention (edema) in your feet, ankles, hands or other parts of the body.
- LOKELMA contains 400 mg of sodium in each 5 g dose. Watch for signs of fluid retention (edema) in your body especially if you limit sodium in your diet or are likely to have fluid retention in your body due to heart or kidney problems. Your doctor may tell you to reduce the sodium in your diet or to increase the dose of your diuretic as needed
If you are a hemodialysis patient:
- Do not take LOKELMA on dialysis days
- Tell your doctor if you suddenly feel sick such as decreased oral intake of food or fluids or have diarrhea, as you may be at risk of developing low levels of potassium in your blood while on LOKELMA; therefore, your dose of LOKELMA may need to be adjusted
Tell your doctor(s) you are taking LOKELMA before having an abdominal X-ray as it may appear on the X-ray.
What are the most common side effects with LOKELMA?
The most common side effect of LOKELMA is swelling in your body caused by fluid retention (edema). Tell your doctor if you have any side effects that bother you or do not go away.
Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements. LOKELMA may affect how some oral medicines work. Ask your doctor or pharmacist if you need to take LOKELMA 2 hours before or after other oral medicines.
APPROVED USE
LOKELMA is a prescription medication for the treatment of high levels of potassium in the blood (hyperkalemia) in adults.
LOKELMA should not be used as an emergency treatment for life-threatening hyperkalemia because of its delayed onset of action.
Please see accompanying US Full Prescribing Information for LOKELMA.
You may report side effects related to AstraZeneca products .
IMPORTANT SAFETY INFORMATION FOR LOKELMA® (sodium zirconium cyclosilicate)
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IMPORTANT SAFETY INFORMATION FOR LOKELMA® (sodium zirconium cyclosilicate)
This product information is intended for US Consumers only.
LOKELMA is a registered trademark and AZ&Me is a trademark of the AstraZeneca group of companies.
©2026 AstraZeneca. All rights reserved.
US-104583; US-112997 Last Updated 6/26
