WHAT IS HIGH POTASSIUM OR HYPERKALEMIA?

Hyperkalemia is the name for a condition where the potassium level in your blood is higher than normal. Potassium is an electrolyte that your body needs in order to keep your muscles, nerves, and heart working well. It's also important for digestive and bone health.

Your blood potassium level should be 3.5 to 5.0 millimoles per liter (mmol/L).

  • You may not have any symptoms, or you may have mild and non-specific symptoms such as nausea, numbness, tingling, and muscle weakness
  • Your potassium level is increased (>5.0 to <5.5 mmol/L)
  • You may have mild symptoms such as weakness or fatigue
  • Your potassium level is increased (5.5-6.0 mmol/L)
  • You may have severe symptoms such as muscle pain, loss of muscle function, and rapid, strong, or irregular heartbeat
  • Your potassium level is very high (>6.0 mmol/L)
  • Having a blood potassium level higher than 6.0 mmol/L can be dangerous and may require immediate treatment

WHAT ARE THE WARNING SIGNS OF HIGH POTASSIUM OR HYPERKALEMIA?

WHAT ARE THE WARNING SIGNS OF HIGH POTASSIUM OR HYPERKALEMIA?

Don’ts Icon
  • Muscle fatigue
  • Weakness
  • Tingling or unusual sensations
Medical Assistance Icon
  • Heart palpitations
  • Shortness of breath
  • Chest pain
  • Paralysis
  • Nausea or vomiting

Don’t delay. Call 911 or go to the emergency room. Sudden or severe high potassium can be a life-threatening condition. Seek immediate medical care.

LOKELMA is indicated for the treatment of hyperkalemia in adults.
LOKELMA should not be used as an emergency treatment for life-threatening hyperkalemia because of its delayed onset of action.

WHAT ARE THE RISKS OF HAVING HIGH POTASSIUM?

Having too much potassium in your blood can be dangerous. Potassium affects the way your heart’s muscles work. When you have too much potassium, your heart may beat irregularly, which in the worst cases, can cause a heart attack.

WHAT ARE THE DIETARY RESTRICTIONS ASSOCIATED WITH HIGH POTASSIUM?

High-potassium foods and drinks are those with more than 200 mg (200 milligrams) of potassium per serving.

Talk to your doctor to see if you need to modify your diet. As a general guide, here are some foods you may want to limit or avoid:

Do’s Icon
  • Apple IconSome fruits such as apples, strawberries, blueberries, grapes, and cranberries
  • Asparagus IconSome vegetables such as asparagus, eggplant, green beans, cauliflower, carrots, and peppers
  • Bread IconRice, noodles, pasta, bread, and bread products (not whole grains)
Don’ts Icon
  • Banana IconCertain fruits such as bananas, oranges, mangoes, avocado, and dried fruit
  • Beets IconSome vegetables such as beets, sweet potatoes, beans (black, pinto, baked), potatoes, and tomatoes
  • Dairy ProductsMilk and yogurt, chocolate, peanut butter, nuts, seeds, and granola
  • Salt substitutes

WHAT IS LOKELMA?

LOKELMA is a prescription medicine for adults with hyperkalemia.

LOKELMA is not absorbed in the body. It binds excess potassium in the intestines and removes the potassium from the body.

LOKELMA can also be taken by patients who are on dialysis treatment.

For patients who are on dialysis:

  • Do not take LOKELMA on dialysis days
  • Tell your doctor if you suddenly feel sick such as decreased oral intake of food or fluids or diarrhea, as you may be at risk of developing low levels of potassium in your blood while on LOKELMA; therefore, your dose of LOKELMA may need to be adjusted
  • Your doctor may monitor your potassium level and adjust your dose. Take LOKELMA as directed by your doctor

HOW DO I TAKE LOKELMA?

It is important to take LOKELMA exactly as prescribed for as long as your doctor prescribes it. If you do not understand the prescription you have been given, please ask your doctor or nurse right away.

When you fill your prescription, you will receive LOKELMA as a white powder in foil-lined packets

For patients not on dialysis:

  • Your initial treatment will be one 10-g packet taken three times a day for up to 48 hours
  • Once you have completed the initial treatment doses, take one 10-g packet once daily to keep your potassium levels lower
  • Your doctor may monitor your potassium level and adjust your dose. Take LOKELMA as directed by your doctor

For patients who are on dialysis:

  • Do not take LOKELMA on dialysis days
  • Tell your doctor if you suddenly feel sick such as decreased oral intake of food or fluids or diarrhea, as you may be at risk of developing low levels of potassium in your blood while on LOKELMA; therefore, your dose of LOKELMA may need to be adjusted
  • Your doctor may monitor your potassium level and adjust your dose. Take LOKELMA as directed by your doctor

How to take LOKELMA at home

Water Guidelines While Taking LOKELMA
  • Fill a drinking glass with approximately 3 tablespoons of water or more if desired
  • Empty the entire contents of the LOKELMA packet(s) into the glass. Stir well and drink immediately
  • If powder remains in the glass, add water, stir, and drink immediately. Repeat until no powder remains
  • If desired, LOKELMA can be taken with or without food
  • If you have been prescribed other oral medications, you may need to take them 2 hours before or 2 hours after taking LOKELMA as your doctor prescribed
  • LOKELMA may affect how some oral medicines work
  • Tell your doctor or pharmacist about all your medications, including prescriptions and over-the-counter medicines, vitamins and herbal supplements
  • Do not take LOKELMA on dialysis days

LOKELMA is tasteless and odorless

WHAT IS THE MOST IMPORTANT THING I SHOULD KNOW ABOUT LOKELMA?

LOKELMA can cause swelling (edema) caused by fluid retention in your body (such as hands, ankles, feet).

  • LOKELMA contains 400 mg of sodium in each 5 g dose. Watch for signs of swelling in your body especially if you limit sodium in your diet or are likely to have fluid retention in your body due to heart or kidney problems. Your doctor may tell you to reduce the sodium in your diet
  • If you are not on dialysis, your doctor may also tell you to increase the dose of your diuretic

If you are a hemodialysis patient:

  • Do not take LOKELMA on dialysis days
  • Tell your doctor if you suddenly feel sick such as decreased oral intake of food or fluids or diarrhea, as you may be at risk of developing low levels of potassium in your blood while on LOKELMA; therefore, your dose of LOKELMA may need to be adjusted

ARE THERE SIDE EFFECTS WHEN TAKING LOKELMA?

The most common side effect of LOKELMA is swelling in your body caused by fluid retention. Tell your doctor if you have any side effects that bother you or do not go away.

IF I STOP TAKING LOKELMA, WILL MY HIGH POTASSIUM COME BACK?

Only your doctor can tell you when and if to stop taking LOKELMA. In clinical studies with LOKELMA, potassium levels stayed lower when treatment with LOKELMA was continued.

HOW LONG SHOULD I TAKE LOKELMA FOR?

You should take LOKELMA exactly as prescribed for as long as it has been prescribed. If you have any questions, reach out to your doctor or pharmacist.

SHOULD I CONTINUE TAKING MY OTHER MEDICATIONS?

Do not stop taking any prescribed medication unless directed by your physician. Talk to your physician about all other medications you are currently taking.

WHAT SHOULD I TELL MY DOCTOR BEFORE TAKING LOKELMA?

Before taking LOKELMA, tell your doctor about all your medical conditions, including

  • problems having a bowel movement, including severe constipation, a blockage (obstruction) in your bowel, or dry hard stool that will not pass out of your rectum (impaction)
  • problems with your bowels after surgery

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What is the most important thing I should know about LOKELMA?

LOKELMA can cause swelling (edema) caused by fluid retention in your body (such as hands, ankles, feet).

  • LOKELMA contains 400 mg of sodium in each 5 g dose. Watch for signs of swelling in your body especially if you limit sodium in your diet or are likely to have fluid retention in your body due to heart or kidney problems. Your doctor may tell you to reduce the sodium in your diet.
  • If you are not on dialysis, your doctor may also tell you to increase the dose of your diuretic.

If you are a hemodialysis patient:

  • Do not take LOKELMA on dialysis days.
  • Tell your doctor if you suddenly feel sick such as decreased oral intake of food or fluids or diarrhea, as you may be at risk of developing low levels of potassium in your blood while on LOKELMA; therefore, your dose of LOKELMA may need to be adjusted.

What should I tell my doctor before taking LOKELMA?

Before taking LOKELMA, tell your doctor about all your medical conditions, including

  • problems having a bowel movement, including severe constipation, a blockage (obstruction) in your bowel, or dry hard stool that will not pass out of your rectum (impaction).
  • problems with your bowels after surgery.

What are the most common side effects with LOKELMA?

The most common side effect of LOKELMA is swelling in your body caused by fluid retention. Tell your doctor if you have any side effects that bother you or do not go away.

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements. LOKELMA may affect how some oral medicines work. Ask your doctor or pharmacist if you need to take LOKELMA 2 hours before or after other oral medicines.

APPROVED USE

LOKELMA is a prescription medication for the treatment of high levels of potassium in the blood (hyperkalemia) in adults.

Please see the full Prescribing Information for LOKELMA.

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